Key result
A low-fat weight-loss diet in participants with higher baseline DNA methylation at CPT1A was associated with a greater reduction in total plasma triglycerides at 2 years (P interaction = 0.018).
Why the study?
CPT1A may be important in triglyceride metabolism, and high fat intake is linked to CPT1A methylation, but its role in triglyceride reductions during weight-loss diets was unknown.
Does baseline DNA methylation at CPT1A modify the effect of a low-fat versus high-fat weight-loss diet on 2-year changes in triglycerides in White participants?
Population
538 White participants
Comparison
1 of 4 diets varying in macronutrient components
Design
Randomized trial
Follow-up
2 years
Authors
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CPT1A methylation may guide low-fat diet selection to optimize triglyceride reductions; extends precision nutrition evidence from RCTs.
RCT (n=538)
randomly assigned
Does baseline DNA methylation at CPT1A modify the effect of a low-fat versus high-fat weight-loss diet on 2-year changes in triglycerides in White participants?
p-value: p=0.018
Higher baseline DNA methylation at CPT1A predicts greater long-term reductions in triglycerides and triglyceride-rich lipoproteins in response to a low-fat weight-loss diet.
Li et al. (2023) conducted an RCT in Weight loss (n=538). Low-fat weight-loss diet vs. High-fat weight-loss diet was evaluated on 2-year changes in total plasma triglycerides (p=0.018). A low-fat weight-loss diet in participants with higher baseline DNA methylation at CPT1A was associated with a greater reduction in total plasma triglycerides at 2 years (P interaction = 0.018).
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