Key result
LDL receptor family members drive the tissue clearance of triglyceride-rich lipoproteins and remnants.
The triglyceride-rich lipoproteins in normal human plasma are VLDL and chylomicrons and their remnants. Several receptors for these lipoproteins have been described, most of them belonging to the LDL receptor family. The LDL receptor itself is able to recognize remnants through apolipoprotein E. However, the LDL receptor-related protein is the actual candidate to be the chylomicron remnant receptor in the liver and the VLDL receptor might be responsible for VLDL catabolism in muscle and adipose tissue.
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Ulrike Beisiegel (1995) conducted a review in Lipoprotein metabolism. Receptors for triglyceride-rich lipoproteins was evaluated. Receptors from the LDL receptor family, such as the LDL receptor-related protein and VLDL receptor, mediate the catabolism of triglyceride-rich lipoproteins and their remnants in various tissues.
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