Key result
Regression from pathological cardiac hypertrophy in mice is sexually dimorphic and stimulus specific, highlighting the need to consider sex differences in therapies.
Why the study?
Pathological cardiac hypertrophy is a major risk factor for mortality, but very little is understood about its regression, why it is not reversible in some individuals, and the role of sex differences.
Answers are grounded in this paper and cite their sources.
Limited insight into hypertrophy regression warrants caution assuming reversibility; leaves open sex-specific mechanisms as targets.
Pathological cardiac hypertrophy is a major risk factor for mortality and is thought to be largely irreversible in many individuals. Although cardiac hypertrophy itself has been studied extensively, very little is understood about its regression. It is important that we have a better understanding of mechanisms leading to regression, why this process is not reversible in some individuals and that sex differences need to be considered when contemplating therapies.
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Muehleman et al. (2022) studied Pathological cardiac hypertrophy. Regression from pathological cardiac hypertrophy in mice is sexually dimorphic and stimulus specific, highlighting the need to consider sex differences in therapies.
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