Key result
Expression of TREK-2b and TREK-2c in HEK 293 cells demonstrated similar single-channel characteristics, with slope conductances of 163 +/- 5 pS and 179 +/- 17 pS at negative potentials, respectively.
Population
cDNA libraries of human kidney and fetal brain, rat brain, and human embryonic kidney 293 cells
Design
Preclinical
Authors
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Similar conductances indicate functional equivalence of TREK-2 isoforms; extends K+ channel diversity but leaves open isoform-specific roles in vivo.
Alternative splicing of TREK-2 generates novel isoforms with distinct tissue expression patterns but similar functional characteristics, contributing to the diversity of two-pore-domain K+ channels.
Gu et al. (2002) studied this question. TREK-2b and TREK-2c expression was evaluated on Single-channel characteristics. Expression of TREK-2b and TREK-2c in HEK 293 cells demonstrated similar single-channel characteristics, with slope conductances of 163 +/- 5 pS and 179 +/- 17 pS at negative potentials, respectively.
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