Key result
Newly cloned TREK-2 tandem-pore K+ channel activates via membrane stretch, acidic pH, and fatty acids.
Why the study?
A new member of the tandem-pore K+ channel family had not been identified and characterized in terms of expression and functional properties.
Population
Rat cerebellum cDNA library and COS-7 cells
Comparison
Expression and functional characterization of TREK-2 channel
Design
Preclinical molecular cloning and electrophysiological study
Authors
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TREK-2 cloning expands tandem-pore K+ channel family; leaves open its roles in cardiac and neuronal excitability.
The study identifies TREK-2 as a novel member of the mechanosensitive and fatty acid-stimulated tandem-pore K+ channel family.
Bang et al. (2000) studied this question. TREK-2 cloning and expression was evaluated on Channel characteristics (conductance, activation). TREK-2 is a newly cloned member of the tandem-pore K+ channel family that is activated by membrane stretch, acidic pH, and unsaturated free fatty acids like arachidonic acid.
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