Key result
The novel cardiac two-pore background K+ channel cTBAK-1 is highly expressed in heart myocytes, producing a Ba2+-sensitive linear background K+ conductance of ~16 pS.
The cloning and characterization of cTBAK-1 identifies a novel two-pore background K+ channel that likely contributes to baseline cardiac cellular electrical activity.
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May inform future cardiac electrophysiology research in animals; leaves open human relevance and therapeutic potential.
Kim et al. (1998) studied this question. The novel cardiac two-pore background K+ channel cTBAK-1 is highly expressed in heart myocytes, producing a Ba2+-sensitive linear background K+ conductance of ~16 pS.
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