TBAK-1 and TASK-1, two-pore K+ channel subunits: kinetic properties and expression in rat heart

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Population

COS-7 cells transiently expressing TBAK-1 or TASK-1, and native rat atrial and ventricular cells

Design

Preclinical

Authors

Discussion

May influence cardiac excitability during acidosis; hypothesis-generating for TBAK-1/TASK-1 roles in human ischemia.

Population

COS-7 cells transiently expressing TBAK-1 or TASK-1, and native rat atrial and ventricular cells

Intervention

Evaluation of TBAK-1 and TASK-1 K+ channel subunits

Outcome

Kinetic properties, pH sensitivity, and regional cardiac mRNA expressionsurrogate

TBAK-1 and TASK-1 are highly pH-sensitive two-pore K+ channel subunits that represent functional native K+ channels in the rat heart.

Kim et al. (1999) studied this question.

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