Population
Rat ventricular cardiomyocytes, mRNA from rat heart, and Xenopus oocytes expressing TASK-1 and other K+…
Comparison
A293, extracellular acidification to pH 6.0, and… vs Baseline conditions or presence of…
Design
Preclinical
Authors
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TASK-1 contributes to rat APD plateau current and is alpha1A-inhibited; leaves open translation to human repolarization or arrhythmia mechanisms.
The TASK-1 potassium channel contributes significantly to the outward current during the action potential plateau in rat cardiomyocytes and is inhibited by alpha1A-adrenergic receptors.
Putzke et al. (2007) studied this question.
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