Cloning and Expression of a Novel pH-sensitive Two Pore Domain K+ Channel from Human Kidney

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Population

Human kidney cDNA library, transfected cells, and human and mouse tissues

Design

Preclinical

Authors

Discussion

Hypothesis-generating for TASK-2 in distal nephron K+ transport; leaves open its physiologic role and any clinical relevance.

Population

Human kidney cDNA library, transfected cells, and human and mouse tissues

Intervention

Cloning, expression, and functional characterization of the TASK-2 K+ channel

Outcome

Electrophysiological properties, pharmacological sensitivity, pH sensitivity, and tissue localization of TASK-2surrogate

The cloning and characterization of TASK-2 reveals a novel pH-sensitive K+ channel localized in the kidney, suggesting a role in renal K+ transport.

Reyes et al. (1998) studied this question.

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