September 1, 1992Circulation ResearchOpen Access

Functional expression of an inactivating potassium channel cloned from human heart.

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Population

Xenopus laevis oocytes

Design

Preclinical

Authors

SPSunny S. PoElectrophysiology DSDirk J. SnydersUniversity of Antwerp RBRachel BakerUniversity of Pennsylvania

Discussion

Member takes

Implication

Cloned human channel recapitulates cardiac Ito properties; leaves open its role in human repolarization and arrhythmia mechanisms.

Structured PICO

Population

Xenopus laevis oocytes

Intervention

Cytoplasmic injections of in vitro transcribed cRNA of a putative human K+ channel cloned from human ventricular myocardium

Outcome

Expression of a functional ion-selective channel and its electrophysiological propertiessurrogate

The cloned human K+ channel DNA encodes a functional, rapidly inactivating, voltage-gated potassium channel with properties similar to the cardiac transient outward current.

Cite This Study

Po et al. (1992) studied this question.

synapsesocial.com/papers/6a71be84660549caf2c64019 https://doi.org/10.1161/01.res.71.3.732

View Full Paper

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Functional expression of an inactivating potassium channel cloned from human heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional expression of an inactivating potassium channel cloned from human heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider