Population
COS cells transiently transfected with a plasmid carrying a cDNA for an inactivation-removed Shaker K+…
Design
Preclinical
Authors
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Enables milligram-scale purification of functional Shaker K+ channels; leaves open validation in mammalian cardiac models.
The study demonstrates the successful high-level expression and functional reconstitution of Shaker K+ channels in a heterologous expression system, enabling future purification of milligram-level amounts of functional channels.
Sun et al. (1994) studied this question.
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