Familial Colonic Cancer Without Antecedent Polyposis

Brief Reports1 May 1984Familial Colonic Cancer Without Antecedent PolyposisC. RICHARD BOLAND, M.D., FRANK J. TRONCALE, M.D.C. RICHARD BOLAND, M.D., FRANK J. TRONCALE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-5-700 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptColorectal carcinoma is primarily caused by environmental factors (1), but a small subset of patients is unusually susceptible to colonic cancer on a familial basis and virtually all family members who inherit the critical gene can be expected to develop cancer eventually. The best known of these syndromes are familial polyposis coli and Gardner's syndrome, both easily recognizable because multiple adenomatous polyps precede the appearance of carcinoma in the colon. Less commonly recognized are the familial colonic cancer syndromes without antecedent polyposis. Such cases are important to recognize because of the serious implications for relatives of those affected.A 38-year-old...References1. DOLL R. General epidemiologic considerations in etiology of colorectal cancer. In: WINAWER SJ, SCHOTTENFELD D, SHERLOCK P. Colorectal Cancer: Prevention, Epidemiology, and Screening. New York: Raven Press; 1980:3-12. (Progress in Cancer Research and Therapy, vol. 13.) Google Scholar2. COPELANDMILLERJONES ELR. Prognostic factors in carcinoma of the colon and rectum. Am J Surg. 1968;116:875-81. CrossrefMedlineGoogle Scholar3. KRUSHLYNCHMAGNUSON AHC. Attitudes toward cancer in a "cancer family": implications for cancer detection. Am J Med Sci. 1965;249:432-8. CrossrefMedlineGoogle Scholar4. LYNCHLYNCHHARRIS PHR. Hereditary proximal colonic cancer. Dis Colon Rectum. 1977;20:661-8. CrossrefMedlineGoogle Scholar5. BEDIKIANKANTARJIANNELSONSTROEHLEINBODEY AHRJG. Colorectal cancer in young adults. South Med J. 1981;74:920-4. CrossrefMedlineGoogle Scholar6. 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