What question did this study set out to answer?

The research aims to investigate the effects of vitamin E supplementation on plasma lipid peroxides and related cardiovascular markers in individuals with hyperlipoproteinemias.

January 1, 1985Thrombosis and Haemostasis

Dietary Supplementation with Vitamin E in Hyperlipoproteinemias: Effects on Plasma Lipid Peroxides, Antioxidant Activity, Prostacyclin Generation and Platelet Aggregability

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The research aims to investigate the effects of vitamin E supplementation on plasma lipid peroxides and related cardiovascular markers in individuals with hyperlipoproteinemias.
Placebo-controlled trial involving healthy volunteers and patients with hyperlipoproteinemias types II and IV.
Participants received 300 mg or 600 mg of vitamin E daily for 2 weeks.
Assessments included serum tocopherol levels, lipid profiles, and platelet aggregability.
Serum tocopherol levels increased two-fold with vitamin E supplementation (P<0.05).
Plasma lipid peroxides were significantly suppressed with vitamin E (600 mg), indicating increased antioxidant activity.
In rabbits, atherogenic diet supplemented with 100 mg of vitamin E prevented elevation of plasma lipid peroxides and preserved prostacyclin generation.

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Implication

Randomized trial shows vitamin E supplementation reduces lipid peroxides in hyperlipoproteinemias, suggesting cardiovascular benefits.

Cite This Study

Szczeklik et al. (1985) studied this question.

synapsesocial.com/papers/6a6377dec1d5a3324809681b https://doi.org/10.1055/s-0038-1657865

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Dietary Supplementation with Vitamin E in Hyperlipoproteinemias: Effects on Plasma Lipid Peroxides, Antioxidant Activity, Prostacyclin Generation and Platelet Aggregability

Key Points

Discussion

Implication

Cite This Study

Dietary Supplementation with Vitamin E in Hyperlipoproteinemias: Effects on Plasma Lipid Peroxides, Antioxidant Activity, Prostacyclin Generation and Platelet Aggregability

Key Points

Discussion

Implication

Cite This Study

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