Key result
Triglyceride-rich lipoproteins, particularly dietary chylomicra, drive lipid peroxide-induced thrombin generation.
Previous studies have shown that lipid peroxides promote thrombin generation in platelet-poor plasma. In the present study, it has been shown that triglyceride-rich lipoproteins, especially chylomicra of dietary origin, are responsible for this procoagulant activity. The generation of thrombin by lipid peroxides is also enhanced by their inhibitory action on antithrombin III. These results suggest a possible new relationship between dietary fat, lipid peroxidation and thrombus formation.
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Barrowcliffe et al. (1984) studied this question. Lipid peroxides and triglyceride-rich lipoproteins was evaluated on Thrombin generation. Triglyceride-rich lipoproteins, particularly dietary chylomicra, were found to be responsible for the procoagulant activity of lipid peroxides in promoting thrombin generation.
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