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Abstract The problem of impaired wound healing poses significant challenges in clinical practice. Factors such as chronic diseases and aging can adversely impact the healing process, leading to delayed wound healing. Additionally, the rise of antibiotic-resistant bacteria poses a threat by increasing the risk of wound infections. As a result, advanced wound dressings, tissue engineering, and bioactive molecules incorporation are being actively used to address these challenges and improve wound-healing outcomes. Biopolymer-based electrospun nanofibers have emerged as a promising approach in the field of wound healing. These nanofibers, composed of biocompatible and biodegradable materials, possess unique properties that mimic the extracellular matrix which make them suitable for promoting effective tissue regeneration. By incorporating various functional groups and bioactive molecules into the biopolymer matrix, the nanofibers can be tailored to exhibit specific properties such as antibacterial, anti-inflammatory, and cell-adhesive properties. Furthermore, the controlled release of therapeutics from the functionalized nanofibers provides localized treatment, promoting efficient healing and minimizing potential side effects. Overall, functionalized biopolymer-based electrospun nanofibers hold great promise as advanced wound dressings, offering a versatile platform for accelerating wound healing and improving patient outcomes. This review is briefly representing the different types of electrospun biopolymers and their different manufacturing techniques in addition to the different ways of functionalization to be used in wound healing.
Basma Ekram (Thu,) studied this question.