Key result
Very low-dose amiodarone (100 mg daily) maintained sinus rhythm similarly to 200 mg daily over 5 years, but with fewer adverse effects requiring withdrawal (0% vs 11%).
Why the study?
Does amiodarone 100 mg daily maintain sinus rhythm as effectively as 200 mg daily in patients with chronic atrial fibrillation and rheumatic heart disease after successful DC cardioversion?
RCT (n=76)
Randomized
Does amiodarone 100 mg daily maintain sinus rhythm as effectively as 200 mg daily in patients with chronic atrial fibrillation and rheumatic heart disease after successful DC cardioversion?
Very low-dose amiodarone (100 mg daily) provides similar long-term efficacy for maintaining sinus rhythm as 200 mg daily but with a better safety profile in patients with chronic AF and rheumatic heart disease.
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Very low-dose amiodarone may aid sinus rhythm maintenance post-cardioversion in RHD; leaves open confirmation via larger randomized trials.
Jong et al. (2006) conducted an RCT in Chronic atrial fibrillation and rheumatic heart disease (n=76). Amiodarone vs. Amiodarone 200 mg daily was evaluated on Maintenance of sinus rhythm. Very low-dose amiodarone (100 mg daily) maintained sinus rhythm similarly to 200 mg daily over 5 years, but with fewer adverse effects requiring withdrawal (0% vs 11%).
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