Key result
Concomitant percutaneous closure of the left atrial appendage and septal defects in patients with enlarged atria but no atrial fibrillation was feasible and safe, with 0% adverse events over 2 years.
Observational (n=13)
Yes
Concomitant LAA closure during percutaneous ASD or PFO closure in patients with enlarged atria but no AF appears feasible and safe, though its clinical justification requires further study.
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Does not support routine use without AF; leaves open benefit and requires prospective trials.
Kuwata et al. (2013) conducted an observational in Large atrial septal defect (ASD) or patent foramen ovale (PFO) with enlarged atria and no atrial fibrillation (n=13). Concomitant percutaneous closure of the left atrial appendage (LAA) and septal defect was evaluated on Primary safety endpoint (composite of death, stroke, tamponade, urgent surgery, or major bleeding) and primary efficacy endpoint (stroke, systemic embolization, or cardiovascular death). Concomitant percutaneous closure of the left atrial appendage and septal defects in patients with enlarged atria but no atrial fibrillation was feasible and safe, with 0% adverse events over 2 years.
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