Key result
Na+ ions act as rapidly diffusible messengers (diffusivity 680 µm2/s) that expand the spatial scale of cytoplasmic pH-CaT interactions to coordinate global Ca2+ signaling during pH non-uniformity.
Population
Rat ventricular myocytes
Comparison
Intracellular acidification and regional acetate… vs Control conditions and NHE1 inhibition with…
Design
Preclinical
Authors
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Extends spatial models of pH-Ca2+ coupling in myocytes; leaves open relevance to human arrhythmias.
Na+ ions act as rapidly diffusible messengers to coordinate global Ca2+ signaling during conditions of intracellular pH non-uniformity in cardiomyocytes.
Swietach et al. (2014) studied this question. Intracellular acidification via acetate exposure was evaluated on Cytoplasmic Na+ diffusivity and Ca2+ transient amplitude. Na+ ions act as rapidly diffusible messengers (diffusivity 680 µm2/s) that expand the spatial scale of cytoplasmic pH-CaT interactions to coordinate global Ca2+ signaling during pH non-uniformity.
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