Colistin disposition in the cerebrospinal fluid when administered either intravenously alone or with intraventricular/intrathecally in neonates/pediatric patients with culture-proven meningitis

Ritika Kondel Bhandari; Avaneesh Kumar Pandey; Nusrat Shafiq; Jogender Kumar; Samir Malhotra; Chakrant Mothsara; Shiv Sajan; Vikas Gautam; Pallab Ray; Naveen Sankhyan; Saurabh Dutta; Praveen Kumar; Ajay Patial; Savita Verma Attri

doi:10.1016/j.pedneo.2021.07.012

January 19, 2022Pediatrics & NeonatologyOpen Access

Colistin disposition in the cerebrospinal fluid when administered either intravenously alone or with intraventricular/intrathecally in neonates/pediatric patients with culture-proven meningitis

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Key Points

Investigate colistin distribution in cerebrospinal fluid for neonates with culture-proven meningitis.
Evaluated colistin levels in cerebrospinal fluid using intravenous and intraventricular/intrathecal routes.
Sample population included neonates and pediatric patients with confirmed meningitis.
Data collection focused on pharmacokinetics of colistin in the central nervous system.
Colistin administered intraventricular demonstrated higher CSF concentrations than intravenous alone.
Significant differences in colistin levels were observed, indicating effective delivery to CNS.
No adverse effects related to the colistin delivery method were reported.

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Implication

Examines colistin in cerebrospinal fluid for meningitis in neonates, suggesting effective treatment options.

Abstract

Nosocomial infections due to cerebrospinal fluid (CSF) in Gram-negative organisms are serious problems in low and middle-income countries (LMIC), involving the central nervous system (CNS) with presentation as either meningitis, ventriculitis, or even abscesses.1 The most common organisms responsible for these infections are multi-drug resistant Gram-negative bacilli, such as Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumonia.2

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Cite This Study

Bhandari et al. (2022) studied this question.

synapsesocial.com/papers/6a63846484b804377828c135 https://doi.org/10.1016/j.pedneo.2021.07.012

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Colistin disposition in the cerebrospinal fluid when administered either intravenously alone or with intraventricular/intrathecally in neonates/pediatric patients with culture-proven meningitis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Colistin disposition in the cerebrospinal fluid when administered either intravenously alone or with intraventricular/intrathecally in neonates/pediatric patients with culture-proven meningitis

Key Points

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Implication

Abstract

Discussion

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