Answers are grounded in this paper and cite their sources.
Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.
No takes yet. Share an insight, caveat, or question.
Margolis et al. (1977) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: