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Review: Control of IRF-3 Activation by Phosphorylation | Synapse

January 1, 2002Journal of Interferon & Cytokine Research160 citations

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Review: Control of IRF-3 Activation by Phosphorylation

MYMitsutoshi Yoneyama WSWakako Suhara TFTakashi Fujita

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Resumen

Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by posttranslational modifications. We review current knowledge of the mechanism of IRF-3 activation: signalling triggered by infections including viruses and bacteria, phosphorylation of IRF-3 on certain serine residues, homodimer formation, and active holocomplex formation with coactivator CBP/p300.

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Cite This Study

Yoneyama et al. (Tue,) studied this question.

synapsesocial.com/papers/6a6385a5a8b6909d49094987 https://doi.org/https://doi.org/10.1089/107999002753452674

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