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December 9, 2017Cancer Prevention ResearchOpen Access

Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice

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Key result

Pioglitazone reduced obesity-related periprostatic white adipose tissue inflammation in mice by inducing adiponectin and suppressing MCP-1 levels.

Why the study?

Does pioglitazone reduce obesity-related periprostatic white adipose tissue inflammation in mice?

Population

Obese mice, MCP-1 knockout mice, and cultured 3T3-L1 cells

Design

Preclinical

Authors

MMMiki MiyazawaKSKotha SubbaramaiahCornell UniversityPBPriya BhardwajCornell University

Discussion

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Implication

Pioglitazone effects on periprostatic inflammation remain unproven in humans; leaves open translation of adiponectin/MCP-1 findings to cancer prevention.

Structured PICO

Does pioglitazone reduce obesity-related periprostatic white adipose tissue inflammation in mice?

P
Population
Obese mice, MCP-1 knockout mice, and cultured 3T3-L1 cells
I
Intervention
Pioglitazone
O
Outcome
Periprostatic white adipose tissue (WAT) inflammation (density of crown-like structures, levels of TNFα, TGFβ, and MCP-1)surrogate

Pioglitazone attenuates obesity-related periprostatic white adipose tissue inflammation via the PPARγ–adiponectin–MCP-1 axis in preclinical models, suggesting a potential mechanism to reduce prostate cancer risk.

Cite This Study

Miyazawa et al. (2017) studied Obesity-related periprostatic white adipose tissue inflammation. Pioglitazone was evaluated on Periprostatic WAT inflammation (density of CLS, levels of TNFα, TGFβ, MCP-1). Pioglitazone reduced obesity-related periprostatic white adipose tissue inflammation in mice by inducing adiponectin and suppressing MCP-1 levels.

synapsesocial.com/papers/6a638bd1cd7899abd6b71706https://doi.org/10.1158/1940-6207.capr-17-0296
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo‐controlled study in polycystic ovary syndrome2007 · 69 citations
  2. 2Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance2006 · 919 citations
  3. 3Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo2005 · 467 citations
  4. 4High Efficiency Lipid-Based siRNA Transfection of Adipocytes in Suspension2009 · 59 citations
  5. 5Serum Lipid Profile and Risk of Prostate Cancer Recurrence: Results from the SEARCH Database2014 · 160 citations