Why the study?
Does pioglitazone improve vascular dysfunction and reduce PVAT-induced oxidative stress in ApoE-/- mice with fructose-induced metabolic syndrome?
Population
Apolipoprotein E-deficient mice fed with standard diet or fructose overload for 8 weeks
Comparison
Pioglitazone for the last 4 weeks vs Without pioglitazone
Design
Preclinical
Follow-up
8 weeks
Authors
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May stabilize plaques in metabolic syndrome models; leaves open translation to human vascular disease.
Does pioglitazone improve vascular dysfunction and reduce PVAT-induced oxidative stress in ApoE-/- mice with fructose-induced metabolic syndrome?
Pioglitazone reduces PVAT-induced oxidative damage and promotes the stability of advanced atherosclerotic plaques in a mouse model of metabolic syndrome.
Quesada et al. (2018) studied this question.
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