Why the study?
Does a high-fat diet induce endothelial dysfunction via periadventitial adipose tissue in C57Bl/6 mice?
Population
Male C57Bl/6 mice (n=30), 3-4 weeks old at baseline.
Comparison
High-fat diet (60% fat of energy) for 8 months. vs Standard laboratory animal diet for 8 months.
Design
Preclinical
Follow-up
8 months
Authors
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PVAT oxidative stress impairs endothelial function in obese mice; leaves open human translation and therapeutic targeting.
Does a high-fat diet induce endothelial dysfunction via periadventitial adipose tissue in C57Bl/6 mice?
Periadventitial adipose tissue promotes endothelial dysfunction in diet-induced obese mice through mechanisms linked to increased NADPH oxidase-derived oxidative stress and pro-inflammatory cytokine production.
Ketonen et al. (2010) studied this question.
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