Key result
A high-fat diet induced adaptative nitric oxide overproduction in perivascular adipose tissue during early obesity, which significantly ameliorated relaxant responses in the mesenteric bed.
Early diet-induced obesity triggers an adaptive, leptin-associated overproduction of nitric oxide in perivascular adipose tissue to preserve vascular function.
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May support compensatory NO signaling preserving vascular function in early obesity; hypothesis-generating and leaves open human translation.
Gil‐Ortega et al. (2010) studied Diet-induced obesity. High-fat diet vs. Low-fat diet (10% kcal from fat) was evaluated on Relaxant responses to acetylcholine and sodium nitroprusside in the whole perfused mesenteric bed. A high-fat diet induced adaptative nitric oxide overproduction in perivascular adipose tissue during early obesity, which significantly ameliorated relaxant responses in the mesenteric bed.