Key result
Changes in the abundance of gamma- and epsilon-subunit mRNAs correlate with changes in the relative density of two classes of acetylcholine receptor channels in rat muscle.
A switch in the relative abundance of gamma- and epsilon-subunit mRNAs is a major mechanism regulating acetylcholine receptor channel properties in muscle.
Supports AChR channel regulation via subunit mRNA switching in rat muscle; hypothesis-generating with no clinical implications yet.
The contents of the mRNAs encoding the gamma- and epsilon-subunits of the nicotinic acetylcholine receptor as well as the single-channel properties of the receptor have been assessed in innervated, denervated and reinnervated rat muscle. The changes in abundance of the gamma- and epsilon-subunit mRNAs correlate with the changes in relative density of two classes of acetylcholine receptor channels. The results support the view that a switch in the relative abundance of the gamma- and epsilon-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle.
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Witzemann et al. (1987) studied this question. Innervation status (innervated, denervated, reinnervated) was evaluated on Abundance of gamma- and epsilon-subunit mRNAs and single-channel properties. Changes in the abundance of gamma- and epsilon-subunit mRNAs correlate with changes in the relative density of two classes of acetylcholine receptor channels in rat muscle.
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