Key result
Rocuronium significantly reduced the mean time required for successful intubation (107.48 seconds) compared to Vecuronium (165.46 seconds) and Atracurium (195.43 seconds).
Why the study?
Does the choice of muscle relaxant (vecuronium, atracurium, rocuronium) affect the rapidity of intubating conditions and quality of laryngoscopic view in uncomplicated patients?
RCT (n=150)
Double-blind
Computer generated randomization chart
No
Does the choice of muscle relaxant (vecuronium, atracurium, rocuronium) affect the rapidity of intubating conditions and quality of laryngoscopic view in uncomplicated patients?
Absolute Event Rate: 107.48% vs 165.46%
p-value: p=<0.001
Optimal muscle relaxant choice for intubation remains uncertain; level 5 comparison leaves open need for RCTs.
The choice of muscle relaxant for endotracheal intubation may be straightforward in selective cases, but in most patients, who are otherwise uncomplicated, poses a dilemma among anesthesiologists and intensivists. The authors examined the most commonly used muscle relaxants (Vecuronium, atracurium and rocuronium) in equipotent doses and compared the most vital parameters, i.e., rapidity of development of clinically acceptable intubating condition and quality of laryngoscopic view.
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Mitra et al. (2013) conducted an RCT in Patients requiring endotracheal intubation for surgery under general anesthesia (n=150). Rocuronium vs. Vecuronium (0.1 mg/kg) and Atracurium (0.5 mg/kg) was evaluated on Time required for successful intubation (p=<0.001). Rocuronium significantly reduced the mean time required for successful intubation (107.48 seconds) compared to Vecuronium (165.46 seconds) and Atracurium (195.43 seconds).
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