Key result
Eight weeks of adherent CPAP therapy (≥4 h/night) significantly reduced aortic pulse wave velocity by 0.66 m/s and central systolic blood pressure by 11.4 mmHg in patients with OSA and metabolic syndrome.
Why the study?
Obstructive sleep apnea and metabolic syndrome promote arterial stiffening, and this pilot study aimed to evaluate arterial stiffness changes after short-term CPAP therapy using the Arteriograph.
Does 8-week continuous positive airway pressure (CPAP) therapy improve arterial stiffness parameters in patients with moderate-severe OSA and metabolic syndrome?
Cohort (n=39)
No
Does 8-week continuous positive airway pressure (CPAP) therapy improve arterial stiffness parameters in patients with moderate-severe OSA and metabolic syndrome?
Short-term CPAP therapy improves markers of arterial stiffness in patients with moderate-to-severe OSA and metabolic syndrome, provided patients adhere to therapy for at least 4 hours per night.
Answers are grounded in this paper and cite their sources.
Adherent short-term CPAP was associated with improved arterial stiffness; leaves open need for RCTs to confirm outcome benefits.
Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate–severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate–severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate–severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = −11.4 mmHg, p = 0.009), aortic pulse wave velocity (aoPWV: Δ = −0.66 m/s, p = 0.03), and aortic augmentation index (aoAix: Δ = −8.25%, p = 0.01) only in patients who used the device for a minimum of 4 h/night (n = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness.
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Zota et al. (2021) conducted a cohort in Moderate-Severe Obstructive Sleep Apnea and Metabolic Syndrome (n=39). Continuous positive airway pressure (CPAP) vs. Baseline / Non-adherent CPAP use (<4 h/night) was evaluated on Change in aortic pulse wave velocity (aoPWV) (Δ = -0.66 m/s, p=0.03). Eight weeks of adherent CPAP therapy (≥4 h/night) significantly reduced aortic pulse wave velocity by 0.66 m/s and central systolic blood pressure by 11.4 mmHg in patients with OSA and metabolic syndrome.
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