Key result
Treatment with Mandibular Advancement Appliance in moderate to severe OSA was associated with higher scores in most quality of life domains, but arterial stiffness did not differ between groups.
Why the study?
OSA reduces quality of life and impairs cardiovascular health, but the comparative effects of CPAP versus mandibular advancement appliances on arterial stiffness and quality of life needed evaluation.
Does CPAP or MAA therapy improve arterial stiffness and quality of life in patients with moderate to severe obstructive sleep apnea?
Cross-Sectional (n=105)
Does CPAP or MAA therapy improve arterial stiffness and quality of life in patients with moderate to severe obstructive sleep apnea?
Treatment of moderate to severe OSA with MAA or CPAP improves quality of life but does not appear to significantly affect arterial stiffness in this cross-sectional analysis.
Answers are grounded in this paper and cite their sources.
MAA may support QoL gains in OSA; leaves open arterial stiffness effects and requires prospective trials before practice change.
BACKGROUND: Obstructive sleep apnea (OSA) is highly associated with a significant reduction in the Quality of Life (QoL) and is associated with deleterious effects on the cardiovascular system. Arterial stiffness is characterized by morphofunctional changes in the arteries and its assessment can be obtained non-invasively mainly through the measurement of pulse wave velocity (PWV). Arterial stiffness has been proposed as a predictor of cardiovascular diseases. OBJECTIVE: To compare arterial stiffness as well as QoL in patients diagnosed with moderate to severe OSA treated with Continuous Positive Airway Pressure (CPAP) or Mandibular Advancement Appliance (MAA) therapies. METHODS: This is a cross-sectional study involving 105 participants diagnosed with moderate to severe OSA categorized into three independent groups: A Non-treated Control Group and CPAP and MAA treated Groups. QoL was assessed by the Quebec Sleep Questionnaire (QSQ) and arterial stiffness was assessed noninvasively by Mobil-O-Graph. RESULTS: saturation (p = 0.011) (evaluated to diagnose the OSA condition before treatment) and Body Mass Index (BMI) (p < 0.001). The MAA group presented higher scores in all QoL domains (p < 0.05), except Social Interactions in relation to the Control group. For the CPAP group, only Nocturnal Symptoms presented significantly higher scores compared to the control group (p = 0.39). For Arterial Stiffness, no statistical differences were observed among comparisons. CONCLUSIONS: Our results show better QoL scores in patients with OSA treated by CPAP and mainly by MAA. Differently, arterial stiffness parameters did not differ between the groups treated with CPAP and MAA and the control group.
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Guimarães et al. (2024) conducted a cross-sectional in moderate to severe obstructive sleep apnea (n=105). Continuous Positive Airway Pressure (CPAP) or Mandibular Advancement Appliance (MAA) vs. Non-treated Control Group was evaluated on Arterial stiffness and Quality of Life. Treatment with Mandibular Advancement Appliance in moderate to severe OSA was associated with higher scores in most quality of life domains, but arterial stiffness did not differ between groups.
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