Key result
Myocardial gene transfer of Adv-betaARKct (5x10^11 viral particles) significantly enhanced left ventricular function and prevented dysfunction induced by 4 hours of cardioplegic arrest compared to PBS.
RCT
randomized
Authors
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Hypothesis-generating for betaARKct in cardioplegic protection; leaves open clinical translation from this in vitro model.
Tevaearai et al. (2001) conducted an RCT in Ventricular dysfunction after cardioplegic arrest. Adv-betaARKct (betaARK1 inhibitor) vs. PBS was evaluated on Left ventricular (LV) function measured by end-diastolic pressure response to preload augmentation, contractility (LV dP/dt(max)), and relaxation (LV dP/dt(min)). Myocardial gene transfer of Adv-betaARKct (5x10^11 viral particles) significantly enhanced left ventricular function and prevented dysfunction induced by 4 hours of cardioplegic arrest compared to PBS.
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