Why the study?
Does adenoviral gene transfer of beta2-adrenergic receptors improve left ventricular contractility and relaxation in a rabbit model of heart failure undergoing mechanical unloading?
Population
Adult New Zealand White rabbits with heart failure induced by coronary artery ligation undergoing…
Comparison
Adenoviral gene transfer of a beta2-adrenergic… vs Saline delivered via the coronary arteries in…
Design
Preclinical, Randomly delivered
Follow-up
5 days
Authors
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Supports preclinical testing of beta2AR gene therapy during unloading; leaves open translation to human heart failure.
Does adenoviral gene transfer of beta2-adrenergic receptors improve left ventricular contractility and relaxation in a rabbit model of heart failure undergoing mechanical unloading?
Gene transfer of beta2-adrenergic receptors acutely enhances functional myocardial recovery in a rabbit model of heart failure undergoing mechanical unloading.
Tevaearai et al. (2002) studied this question.
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