Key result
Serum HDL cholesterol <1.09 mmol/l was associated with a 3.3-fold increased risk of acute myocardial infarction (HR 3.3; 95% CI 1.7-6.4) in eastern Finnish men.
Why the study?
Do low serum concentrations of HDL, HDL2, and HDL3 cholesterol increase the risk of acute myocardial infarction in middle-aged men?
Population
1,799 randomly selected men aged 42, 48, 54, or 60 years old from eastern Finland
Comparison
Low serum concentrations of HDL, HDL2, and HDL3… vs Higher serum concentrations of HDL, HDL2, and…
Design
Cohort
Authors
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May signal higher MI risk in middle-aged men; leaves open causality and intervention targets.
Cohort (n=1,799)
Do low serum concentrations of HDL, HDL2, and HDL3 cholesterol increase the risk of acute myocardial infarction in middle-aged men?
Hazard Ratio: 3.3 (95% CI 1.7–6.4)
Low levels of total HDL and HDL2 cholesterol are strongly associated with an increased risk of acute myocardial infarction, supporting their protective role in ischemic heart disease.
Salonen et al. (1991) conducted a cohort in Acute myocardial infarction (n=1,799). Low serum HDL cholesterol (<1.09 mmol/l) vs. Higher serum HDL cholesterol was evaluated on Acute myocardial infarction (HR 3.3, 95% CI 1.7-6.4). Serum HDL cholesterol <1.09 mmol/l was associated with a 3.3-fold increased risk of acute myocardial infarction (HR 3.3; 95% CI 1.7-6.4) in eastern Finnish men.
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