HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the lipoprotein investigators collaborative
Why the study?
Is the lowest tertile of HDL3-C associated with an increased risk of mortality and myocardial infarction in secondary prevention patients?
Population
4,879 patients in secondary prevention from two prospective cohorts: TRIUMPH and IHCS.
Comparison
Lowest tertile of HDL3-C subclass measured by… vs Middle tertile of HDL3-C
Design
Cohort
Follow-up
2 years (TRIUMPH) and 5 years (IHCS)
Authors
Discussion
Loading...
Member takes
Overview
May identify residual risk in secondary prevention; hypothesis-generating and should not yet change practice.
Structured PICO
Is the lowest tertile of HDL3-C associated with an increased risk of mortality and myocardial infarction in secondary prevention patients?
P
Population
4,879 patients in secondary prevention from two prospective cohorts: TRIUMPH (n=2,465 acute myocardial infarction patients, mean age 58.2 ± 12.2 years, 68.0% men) and IHCS (n=2,414 patients who underwent coronary angiography, mean age 62.6 ± 12.6 years, 65.5% men).
I
Intervention
Lowest tertile of HDL3-C subclass measured by vertical-spin density gradient ultracentrifugation
C
Comparator
Middle tertile of HDL3-C (and other HDL subclasses HDL-C, HDL2-C)
O
Outcome
Mortality (in TRIUMPH cohort) and composite of mortality or myocardial infarction (in IHCS cohort)hard clinical
Low levels of the HDL3-C subclass, but not total HDL-C or HDL2-C, are independently associated with an increased risk of long-term hard clinical events in secondary prevention patients.
Cite This Study
Martin et al. (2014) studied this question.