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July 25, 2014European Journal of Preventive CardiologyOpen Access

Association of high-density lipoprotein subclasses and incident coronary heart disease: The Jackson Heart and Framingham Offspring Cohort Studies

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Why the study?

Are HDL-C subclasses (HDL2 and HDL3) associated with incident coronary heart disease in primary prevention cohorts?

Population

4,932 participants from two primary prevention cohorts: 4,114 African American participants from the Jackson…

Design

Cohort

Authors

PJParag H. JoshiPreventive CardiologyPTPeter P. TóthPreventive CardiologySLSeth T. LiretteJackson Memorial Hospital

Discussion

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Overview

HDL3-C may drive HDL-C's inverse CHD link in primary prevention; hypothesis-generating for subclass-specific risk models and trials.

Structured PICO

Are HDL-C subclasses (HDL2 and HDL3) associated with incident coronary heart disease in primary prevention cohorts?

P
Population
4,932 participants from two primary prevention cohorts: 4,114 African American participants from the Jackson Heart Study (mean age 53.8 years, 64% female) and 818 predominantly Caucasian participants from the Framingham Offspring Cohort Study (mean age 57.3 years, 52% female).
I
Intervention
Baseline levels of HDL-C subclasses (larger, more buoyant HDL2 and smaller, denser HDL3) separated by density gradient ultracentrifugation.
O
Outcome
Incident CHD events including myocardial infarction, CHD death, and revascularization.composite

Smaller, denser HDL3-C levels are primarily responsible for the inverse association between HDL-C and incident coronary heart disease, which may inform the interpretation of clinical trials utilizing HDL-C therapeutics.

Cite This Study

Joshi et al. (2014) studied this question.

synapsesocial.com/papers/6a7cd67ae83b38d3217bf3a4https://doi.org/10.1177/2047487314543890
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.1989 · 3,195 citations
  2. 2General Cardiovascular Risk Profile for Use in Primary Care2008 · 7,624 citations
  3. 3HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the lipoprotein investigators collaborative2014 · 177 citations
  4. 4HDL, HDL2, and HDL3 subfractions, and the risk of acute myocardial infarction. A prospective population study in eastern Finnish men.1991 · 364 citations
  5. 5Laboratory Assessment of HDL Heterogeneity and Function2008 · 188 citations