Speeding of Vo2 kinetics with endurance training in old and young men is associated with improved matching of local O2 delivery to muscle O2 utilization

The time course and mechanisms of adjustment of pulmonary oxygen uptake (V(O(2))) kinetics (time constant tauV(O(2p))) were examined during step transitions from 20 W to moderate-intensity cycling in eight older men (O; 68 +/- 7 yr) and eight young men (Y; 23 +/- 5 yr) before training and at 3, 6, 9, and 12 wk of endurance training. V(O(2p)) was measured breath by breath with a volume turbine and a mass spectrometer. Changes in deoxygenated hemoglobin concentration (DeltaHHb) were measured by near-infrared spectroscopy. V(O(2p)) and DeltaHHb were modeled with a monoexponential model. Training was performed on a cycle ergometer three times per week for 45 min at approximately 70% of peak V(O(2)). Pretraining tauV(O(2p)) was greater (P < 0.05) in O (43 +/- 10 s) than Y (34 +/- 8 s). tauV(O(2p)) decreased (P < 0.05) by 3 wk of training in both O (35 +/- 9 s) and Y (22 +/- 8 s), with no further changes thereafter. The pretraining overall adjustment of DeltaHHb was faster than tauV(O(2p)) in both O and Y, resulting in DeltaHHb/V(O(2p)) displaying an "overshoot" during the transient relative to the subsequent steady-state level. After 3 wk of training the DeltaHHb/V(O(2p)) overshoot was attenuated in both O and Y. With further training, this overshoot persisted in O but was eliminated after 6 wk in Y. The training-induced speeding of V(O(2p)) kinetics in O and Y at 3 wk of training was associated with an improved matching of local O(2) delivery to muscle V(O(2)) (as represented by a lower DeltaHHb/V(O(2p))). The continued overshoot in DeltaHHb/V(O(2p)) in O may reflect a reduced vasodilatory responsiveness that may limit muscle blood flow distribution during the on-transient of exercise.