Key result
Changes in the properties of Ca2+ transients carry information responsible for remodelling the cardiac gene transcription programme, leading to hypertrophy and congestive heart failure.
Changes in Ca2+ transient properties drive cardiac gene transcription remodelling, leading to hypertrophy and heart failure.
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Does not support clinical translation in hypertrophy; leaves open whether signalosome targeting alters progression.
Michael J. Berridge (2006) conducted a review in Cardiac hypertrophy and congestive heart failure. Ca2+ signalling was evaluated. Changes in the properties of Ca2+ transients carry information responsible for remodelling the cardiac gene transcription programme, leading to hypertrophy and congestive heart failure.
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