Key result
Blood pressure reductions by calcium channel blockers, HCTZ, and ACE inhibitor/HCTZ combinations were significantly greater than placebo in Caribbean Hispanic patients with essential hypertension.
Why the study?
Do various antihypertensive agents (ACE inhibitors, beta blockers, calcium channel blockers, HCTZ) effectively reduce blood pressure compared to placebo in Caribbean Hispanic patients with essential hypertension?
Population
n=89 Caribbean Hispanic patients with essential hypertension, featuring multiple risk factors, left…
Comparison
Antihypertensive therapy including… vs Placebo.
Design
Cohort, Patients participated in six randomized trials, Double-blind
Follow-up
8-12 weeks
Authors
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Low-renin, salt-sensitive hypertension predominates in Caribbean Hispanics; leaves open whether phenotype-specific therapy improves outcomes in this understudied group.
RCT (n=89)
double-blind
randomized
Do various antihypertensive agents (ACE inhibitors, beta blockers, calcium channel blockers, HCTZ) effectively reduce blood pressure compared to placebo in Caribbean Hispanic patients with essential hypertension?
Essential hypertension in Caribbean Hispanics is predominantly a low-renin, salt-sensitive phenotype that responds better to calcium channel blockers and diuretics than to ACE inhibitors or beta blockers alone.
Laffer et al. (2002) conducted an RCT in Essential hypertension (n=89). Antihypertensive agents (calcium channel blockers, HCTZ, ACE inhibitors, beta blockers, ACE inhibitor/HCTZ combinations) vs. Placebo was evaluated on Blood pressure reduction. Blood pressure reductions by calcium channel blockers, HCTZ, and ACE inhibitor/HCTZ combinations were significantly greater than placebo in Caribbean Hispanic patients with essential hypertension.
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