What question did this study set out to answer?

This research examines the density of atrial natriuretic peptide binding sites on platelets in patients with severe congestive heart failure.

February 1, 1988Clinical Science

Decreased density of binding sites for atrial natriuretic peptide on platelets of patients with severe congestive heart failure

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Population

24 patients with functional class III-IV congestive heart failure and 16 age-matched patients without…

Design

Case-control

Authors

ESErnesto L. SchiffrinMedical Council of Canada

Discussion

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Implication

Reduced platelet ANP-binding sites in CHF may signal receptor downregulation; leaves open effects on natriuretic peptide responsiveness pending prospective validation.

Key Points

This research examines the density of atrial natriuretic peptide binding sites on platelets in patients with severe congestive heart failure.
Investigated binding sites in 24 patients with functional class III-IV congestive heart failure
Compared plasma ANP concentrations with 16 age-matched non-cardiac controls
Analyzed the correlation of ANP-binding site density with plasma ANP levels
Plasma ANP levels significantly higher in CHF patients (90.3 +/- 13.4 fmol/ml) compared to controls (15.4 +/- 2.0 fmol/ml), P < 0.001
ANP-binding site density lower in CHF patients (6.3 +/- 0.8 fmol/10^9 cells) versus controls (11.8 +/- 1.4 fmol/10^9 cells), P < 0.01
Inverse correlation observed between ANP-binding site density and plasma ANP concentration.

Structured PICO

Population

24 patients with functional class III-IV congestive heart failure (CHF) and 16 age-matched patients without cardiac disease (total n=40).

Comparator

16 age-matched patients without cardiac disease

Outcome

Density of ANP-binding sites on platelets and plasma ANP concentrationsurrogate

Patients with severe congestive heart failure exhibit a decreased density of ANP-binding sites on platelets, which inversely correlates with their elevated plasma ANP levels.

Cite This Study

Ernesto L. Schiffrin (1988) studied this question.

synapsesocial.com/papers/6a1ec4adbf2a5d44faaf4bef https://doi.org/10.1042/cs0740213

Topics

Heart failure HFrEF treatment

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Implication

Reduced platelet ANP-binding sites in CHF may signal receptor downregulation; leaves open effects on natriuretic peptide responsiveness pending prospective validation.

Decreased density of binding sites for atrial natriuretic peptide on platelets of patients with severe congestive heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Decreased density of binding sites for atrial natriuretic peptide on platelets of patients with severe congestive heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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