Why the study?
Are plasma ANP concentrations and platelet ANP receptor densities altered in patients with essential hypertension compared to healthy controls?
Population
Ambulatory patients with essential hypertension and healthy normotensive controls, maintained on a 135…
Design
Cross-sectional
Authors
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Hypothesis-generating for ANP dysregulation in severe hypertension; prospective studies needed before clinical relevance.
Are plasma ANP concentrations and platelet ANP receptor densities altered in patients with essential hypertension compared to healthy controls?
Moderate to severe uncontrolled essential hypertension with left ventricular hypertrophy is associated with elevated plasma ANP and down-regulated platelet ANP receptors.
Schiffrin et al. (1988) studied this question.
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