Why the study?
Are plasma levels of atrial natriuretic factor (ANF) and cardiac diastolic function altered in patients with untreated essential hypertension compared to normotensive controls?
Population
38 patients with untreated essential hypertension and 31 well-matched normotensive controls
Design
Case-control
Authors
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Elevated ANF may mark diastolic impairment in untreated hypertension; hypothesis-generating and should not yet change practice.
Are plasma levels of atrial natriuretic factor (ANF) and cardiac diastolic function altered in patients with untreated essential hypertension compared to normotensive controls?
In patients with essential hypertension, elevated ANF levels are associated with impaired cardiac diastolic function.
Pontremoli et al. (1993) studied this question.
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