October 1, 1991Clinical Science
Plasma atrial natriuretic peptide concentration and platelet atrial natriuretic peptide binding site density in ageing and hypertension
Structured PICO
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Population
64 subjects, comprising 18 young, 11 middle-aged, and 12 elderly healthy subjects, and 23 patients with mild to moderate essential hypertension.
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Outcome
Plasma atrial natriuretic peptide concentration and platelet atrial natriuretic peptide binding site densitysurrogate
Plasma atrial natriuretic peptide concentration increases with age and in mild to moderate hypertension, but these elevations are insufficient to induce down-regulation of platelet ANP binding site density.
Authors
Discussion
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Implication
Elevated ANP with age and hypertension leaves platelet binding sites unchanged; hypothesis-generating for compensatory mechanisms in cardiovascular aging.
Cite This Study
Duggan et al. (1991) studied this question.