What does this research mean for the field?

Mild essential hypertension is not associated with increased plasma atrial natriuretic factor (ANF) concentrations, whereas ANF levels increase with age in both normotensive and hypertensive individuals and are elevated in patients with renovascular hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess whether circulating concentrations of atrial natriuretic factor differ among patients with mild essential hypertension, renovascular hypertension, and normotensive controls.

May 16, 1987BMJOpen Access

Plasma atrial natriuretic factor concentrations in essential and renovascular hypertension.

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Why the study?

Are plasma atrial natriuretic factor concentrations elevated in patients with essential or renovascular hypertension compared to normotensive controls?

Population

44 patients with mild untreated essential hypertension, 48 normotensive controls, and 15 hypertensive…

Comparison

Measurement of plasma atrial natriuretic factor… vs Normotensive controls

Design

Cross-sectional

Authors

PLPierre LarochelleSouth Dakota School of Mines and Technology JCJean R. CussonMedical Council of Canada JGJolanta GutkowskaHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

ANF measurement adds little to mild essential hypertension evaluation; leaves open its biomarker role in renovascular disease.

Key Points

To assess whether circulating concentrations of atrial natriuretic factor differ among patients with mild essential hypertension, renovascular hypertension, and normotensive controls.
Measured peripheral venous plasma atrial natriuretic factor concentrations in 44 untreated patients with mild essential hypertension and 48 normotensive controls.
Sampled plasma atrial natriuretic factor during renal vein catheterisation in 15 hypertensive patients, including 8 with renovascular hypertension.
Venous plasma atrial natriuretic factor concentrations were 13.2 (SEM 1.5) ng/l in mild essential hypertension and 13.0 (1.3) ng/l in normotensive controls.
Plasma atrial natriuretic factor concentrations correlated significantly with age in both essential hypertensive and normotensive groups.
All 8 patients with renovascular hypertension exhibited increased atrial natriuretic factor concentrations in both the aorta and the inferior vena cava.

Structured PICO

Are plasma atrial natriuretic factor concentrations elevated in patients with essential or renovascular hypertension compared to normotensive controls?

Population

44 patients with mild untreated essential hypertension, 48 normotensive controls, and 15 hypertensive patients undergoing renal vein catheterisation (8 with renovascular hypertension).

Intervention

Measurement of plasma atrial natriuretic factor (ANF) concentrations

Comparator

Normotensive controls

Outcome

Plasma atrial natriuretic factor concentrationssurrogate

Mild essential hypertension is not associated with increased plasma atrial natriuretic factor concentrations, unlike renovascular hypertension.

Cite This Study

Larochelle et al. (1987) studied this question.

synapsesocial.com/papers/6a1bc2a700ee29383e9cd72b https://doi.org/10.1136/bmj.294.6582.1249

Topics

Hypertension management

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Plasma atrial natriuretic factor concentrations in essential and renovascular hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Plasma atrial natriuretic factor concentrations in essential and renovascular hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider