Key result
Fetal adaptation to undernutrition linked to permanent changes driving adult cardiovascular disease and diabetes.
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Recent findings suggest that many human fetuses have to adapt to a limited supply of nutrients and in doing so they permanently change their physiology and metabolism. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders: stroke, diabetes and hypertension.
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D J Barker (1995) studied this question. Fetal adaptation to a limited nutrient supply induces permanent physiological changes that may be the origin of adult coronary heart disease, stroke, diabetes, and hypertension.
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