Key result
In Asian Indian families, moderate to high heritability was observed for cardiovascular risk factors, with BMI heritability ranging from 0.31 to 0.69 and systolic blood pressure from 0.16 to 0.44.
Observational
No
There is moderate to high heritability for body fat, body composition, and blood pressure measures among Asian Indian families, indicating significant genetic aggregation of CVD risk factors.
Supports family-based CVD risk assessment in Asian Indians; leaves open causal validation and clinical translation.
The genetic causes of the components of cardiovascular disease (CVD) risk factors and their intercorrelation are indeed complex and only partly understood. Keeping this view in mind, the present work was undertaken to estimate the heritability of conventional CVD risk factors using family study method. A total of twenty-four nuclear families inhabiting in Calcutta and adjacent areas was chosen randomly. Up to first degree relatives including father, mother and other sibs of the proband were considered as participants in the study. Anthropometric measures namely height, weight, waist circumference as well as skinfold thickness at biceps, triceps, subscapular and suprailiac were obtained using standard techniques. Body mass index (BMI), percentage of body fat (PBF), fat mass (FM), waist-hip ratio (WHR), sum of four skinfolds (SF(4) ), arm muscle circumference (AMC), arm muscle area (AMA), arm fat area (AFA), systolic (SBP) and diastolic blood pressure (DBP) were also considered. To estimate'heritability' in the study, the mid parent-offspring model was used where'heritability' (h(2) ) was equivalent to regression co-efficient (b). The regression sum of square (RSS) and total sum of square (TSS) ratio was also calculated both for mid parent-offspring and single parent-offspring. This ratio was considered as a measure of'heritability' in the study with consideration that RSS is the variation due to genetic factor and the TSS is due to genetic and other additive factor. It was observed that the estimated heritability for BMI ranges from 0.69 to 0.31 using mid-parent off spring model while the range using single parent-offspring model was from 0.40 to 0.16. The range of heritability for SBP in mid parent-offspring model was 0.16 to 0.44 and 0.05 to 0.54 for single parent-offspring model. To conclude, it seems reasonable to argue that in the study a moderate to high h(2) was evident for body fat level, body composition and blood pressure measures which indicate a moderate to high aggregation of gene(s) in the family.
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Ghosh et al. (2010) conducted an observational in Cardiovascular disease risk factors. Genetic inheritance (heritability) was evaluated on Heritability (h2) of cardiovascular risk factors including BMI and systolic blood pressure. In Asian Indian families, moderate to high heritability was observed for cardiovascular risk factors, with BMI heritability ranging from 0.31 to 0.69 and systolic blood pressure from 0.16 to 0.44.
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