Answers are grounded in this paper and cite their sources.
Trifluoromethylation of alkyl radicals is emerging as a powerful tool for C(sp 3 )–CF 3 bond formations. Based on the hypothesis of CF 3 group transfer from Cu(II)–CF 3 to alkyl radicals, a number of trifluoromethylation reactions have been developed, including trifluoromethylation of alkyl halides, decarboxylative trifluoromethylation of aliphatic carboxylic acids, C(sp 3 )–H trifluoromethylation, amino‐ and carbo‐trifluoromethylation of alkenes, etc . Challenges in this intriguing field are also discussed.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2020) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: