Key result
Excessive use of remaining tibialis anterior motor units was correlated with an increased percentage of type 1 muscle fibers (r = 0.69) and type 1 fiber size (r = 0.78).
Why the study?
Does excessive use of remaining muscle fibers affect fiber type composition and size in subjects with prior polio or LV lesion?
Population
23 subjects with weakness of musculus tibialis anterior due to prior poliomyelitis or prior LV lesion
Comparison
Excessive use of remaining TA motor units during… vs Subjects who did not use remaining TA fibers…
Design
Cross-sectional
Authors
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Hypothesis-generating for overuse-driven fiber adaptation; leaves open clinical relevance in neuromuscular disease.
Observational (n=23)
Does excessive use of remaining muscle fibers affect fiber type composition and size in subjects with prior polio or LV lesion?
Effect estimate: r = 0.69 for type 1 percentage; r = 0.78 for type 1 size
Long-term overuse of remaining motor units in partially paralyzed muscles induces a transition to type 1 muscle fibers and marked hypertrophy, regardless of the underlying etiology.
Borg et al. (1988) conducted an observational in Weakness of musculus tibialis anterior due to prior poliomyelitis or prior LV lesion (n=23). Excessive use of remaining TA motor units vs. Subjects who did not use remaining TA fibers because of too-severe paralysis was evaluated on Type 1 muscle fiber percentage and size (r = 0.69 for type 1 percentage; r = 0.78 for type 1 size). Excessive use of remaining tibialis anterior motor units was correlated with an increased percentage of type 1 muscle fibers (r = 0.69) and type 1 fiber size (r = 0.78).
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