October 1, 1989Journal of Neurology Neurosurgery & PsychiatryOpen Access

Motoneuron firing and isomyosin type of muscle fibres in prior polio.

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Population

8 subjects with prior polio with more than 90% type I fibres in the tibialis anterior (TA)

Design

Cross-sectional

Authors

KBKristian BorgDanderyds sjukhus JBJörgen BorgKarolinska Institutet GDGurtej K. DhootUniversity of London

Discussion

Member takes

Implication

Challenges selective motor unit loss assumption in prior polio; supports fiber-type transition but leaves open prospective confirmation.

Structured PICO

Population

8 subjects with prior polio with more than 90% type I fibres in the tibialis anterior (TA)

Intervention

Examination of motoneuron firing and histochemical markers (monoclonal antibodies against fast and slow myosin heavy chains)

Outcome

Proportion of motoneurons with high threshold and high axonal conduction velocity, and binding of anti-fast and anti-slow MHCsurrogate

The type I muscle fibre dominance in prior polio subjects is likely due to a muscle fibre transition from type II to type I rather than a selective loss of motor units.

Cite This Study

Borg et al. (1989) studied this question.

synapsesocial.com/papers/6a7a185fbdf697b3de028105 https://doi.org/10.1136/jnnp.52.10.1141

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Motoneuron firing and isomyosin type of muscle fibres in prior polio.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Motoneuron firing and isomyosin type of muscle fibres in prior polio.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider