Key result
Overexpression of miR-200a-3p significantly ameliorated diabetes-induced cardiac dysfunction, myocardial injury, fibrosis, apoptosis, and inflammation in a mouse model.
Why the study?
To explore the role and mechanism of miR-200a-3p in diabetic cardiomyopathy.
Does miR-200a-3p overexpression alleviate diabetic cardiomyopathy injury in mice?
Population
db/db mice
Comparison
Tail vein injection of rAAV-miR-200a-3p vs controls
Design
Animal model experimental study
Follow-up
8 weeks
Authors
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miR-200a-3p modulation merits human DCM trials; leaves open therapeutic translation from this animal model.
Does miR-200a-3p overexpression alleviate diabetic cardiomyopathy injury in mice?
Overexpression of miR-200a-3p alleviates diabetic cardiomyopathy injury in mice by enhancing autophagy through the FOXO3/Mst1/Sirt3/AMPK axis.
You et al. (2023) studied Diabetic cardiomyopathy. rAAV-miR-200a-3p was evaluated on Cardiac function and pathological changes (myocardial injury, fibrosis, apoptosis, autophagy, inflammation). Overexpression of miR-200a-3p significantly ameliorated diabetes-induced cardiac dysfunction, myocardial injury, fibrosis, apoptosis, and inflammation in a mouse model.
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