Key result
Continuous infusion of the beta-blocker esmolol significantly attenuated myocardial dysfunction, maintaining higher cardiac work and efficiency compared to control in septic rats.
Why the study?
Does esmolol infusion improve myocardial function in a rat model of peritonitis-induced sepsis?
Does esmolol infusion improve myocardial function in a rat model of peritonitis-induced sepsis?
In a rat model of sepsis, esmolol infusion improved myocardial oxygen utilization and preserved myocardial function.
Answers are grounded in this paper and cite their sources.
Esmolol attenuated myocardial dysfunction in septic rats; leaves open whether beta1-blockade improves outcomes in human sepsis.
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Suzuki et al. (2005) studied Sepsis (n=38). Esmolol vs. Saline was evaluated on Cardiac work and cardiac efficiency (p=<0.05). Continuous infusion of the beta-blocker esmolol significantly attenuated myocardial dysfunction, maintaining higher cardiac work and efficiency compared to control in septic rats.
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