Key result
The primary determinants of sustained exercise hyperemia in skeletal muscle are metabolic vasodilation and increased vascular conductance via the muscle pump, alongside sympathetic neural control.
Design
Review
Authors
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Supports established muscle perfusion physiology; leaves open therapeutic translation in cardiovascular disease.
This review highlights that metabolic vasodilation and the muscle pump are the primary drivers of skeletal muscle perfusion during sustained exercise.
Delp et al. (1998) conducted a review in Skeletal muscle perfusion during exercise. Exercise was evaluated. The primary determinants of sustained exercise hyperemia in skeletal muscle are metabolic vasodilation and increased vascular conductance via the muscle pump, alongside sympathetic neural control.
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